Lion’s Mane protects against Dementia
Aging diseases of the nervous system, such as dementia, Alzheimer's, brain tumors and others represent a major global public health crisis, as there are currently no cures. Thus, these diseases have attracted the interest of the leading pharmaceutical companies, who continue to look for possible cures.
How does lion’s mane works?
Bioactive substances isolated from Hericium erinaceus, including its mycelia and fruiting bodies, were discovered to increase the expression of neurotropic factors like nerve growth factor (NGF).
Nerve growth factor is required for neuronal cell development, maintenance proliferation, and organizing the function of cholinergic neurons of the basal forebrain complex (BFC) of the central nervous system of which neurons degrade as dementia progresses  .
In the hippocampus, extracts of Hericium erinaceus were observed to enhance both NGF mRNA and protein expression, suggesting that the bioactive substances in Hericium erinaceus extract can penetrate the blood brain barrier, resulting in hippocampus regeneration.